EXPRESSION OF THE CELL CYCLE REGULATION PROTEINS P53 AND P21WAF1 IN DIFFERENT TYPES OF NON-DYSPLASTIC LEUKOPLAKIAS

Expression of the cell cycle regulation proteins p53 and p21WAF1 in different types of non-dysplastic leukoplakias

OBJECTIVES: The aim of this study Bike Parts - Cables was to analyze the immunolabeling of two cell cycle protein regulators, p53 and p21WAF1, in non-dysplastic leukoplakias with different epithelial alterations: acanthosis, hyperkeratosis and acanthosis combined with hyperkeratosis, and compare them with dysplastic leukoplakias.MATERIAL AND METHOD

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Should antiviral monotherapy with nucleotide analogs be the primary treatment option for focal segmental glomerulosclerosis-related nephrotic syndrome in chronic hepatitis B infection?

Renal involvement is the most common extrahepatic manifestation of chronic hepatitis B virus (HBV) infection.While membranous nephropathy is the most frequent, the association with focal segmental glomerulosclerosis (FSGS) is not as strong, and only a few cases have been described in the literature.In particular, the tip variant FSGS is extremely r

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Mucosal vaccines for SARS-CoV-2: triumph of hope over experience

Summary: Currently approved COVID-19 vaccines administered parenterally induce robust systemic humoral and cellular responses.While highly effective against severe disease, there is reduced effectiveness of these vaccines in preventing breakthrough infection and/or onward transmission, likely due to poor immunity elicited at the respiratory mucosa.

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